Clinical Studies
NMN (Nicotinamide Mononucleotide)
We've compiled transparent credible research and human clinical studies for our ingredients used in Simply Nootropics formulas.
The efficacy and safety of β-nicotinamide mononucleotide (NMN)
Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men.
The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials
Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial.
Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study
Nicotinamide mononucleotide (NMN) intake increases plasma NMN and insulin levels in healthy subjects
Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial
Effects of nicotinamide mononucleotide on older patients with diabetes and impaired physical performance: A prospective, placebo-controlled, double-blind study
Clinical evaluation of changes in biomarkers by oral intake of NMN
Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study
Ashwagandha
Ashwagandha, also known as Indian Ginseng, is a renowned adaptogenic herb used traditionally to alleviate stress and enhance vitality. Also Known As: Withania somnifera (scientific name), Winter Cherry.
A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy
An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda
Safety of Ashwagandha Root Extract: A Randomized, Placebo-Controlled, Study in Healthy Volunteers
Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract
Alpha Lipoic Acid
Alpha Lipoic Acid (ALA) is a naturally occurring compound that functions as a powerful antioxidant in the body. Also Known As: Thioctic Acid.
Cognitive and Mood Effect of Alpha-Lipoic Acid Supplementation in a Nonclinical Elder Sample: An Open-Label Pilot Study
Alpha-lipoic acid as a new treatment option for Alzheimer's disease—a 48 months follow-up analysis
Alpha lipoic acid treatment in late middle age improves cognitive function: Proteomic analysis of the protective mechanisms in the hippocampus
Antioxidants for Alzheimer Disease: A Randomized Clinical Trial With Cerebrospinal Fluid Biomarker Measures
Alleviative Effect of Alpha-Lipoic Acid on Cognitive Impairment in High-Fat Diet and Streptozotocin-Induced Type 2 Diabetic Rats
Bacopa Monnieri
Bacopa Monnieri, commonly known as Brahmi, is a staple plant in traditional Ayurvedic medicine, revered for its cognitive-enhancing properties. Also Known As: Water Hyssop, Herb of Grace.
Bacopa monnieri as an Antioxidant Therapy to Reduce Oxidative Stress in the Aging Brain
The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data
The Neurocognitive Effects of Bacopa Monnieri and Cognitive Training on Markers of Brain Microstructure in Healthy Older Adults
Pharmacological attributes of Bacopa Monnieri extract: Current updates and clinical manifestation
Bacopa Monnieri modulates antioxidant responses in brain and kidney
Citicoline
Citicoline, also known as CDP-Choline (Cytidine Diphosphate-Choline), is a naturally occurring brain chemical that functions as a cognitive enhancer. Cytidine 5'-diphosphocholine.
Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Citicoline Improves Human Vigilance and Visual Working Memory: The Role of Neuronal Activation and Oxidative Stress
Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Is Citicoline Effective in Preventing and Slowing Down Dementia?—A Systematic Review and a Meta-Analysis
Citicoline: A Novel Therapeutic Agent with Neuroprotective, Neuromodulatory, and Neuroregenerative Properties
CoenzymeQ10 (CoQ10)
Coenzyme Q10, often abbreviated as CoQ10, is a naturally occurring antioxidant that plays a critical role in cellular energy production. Also Known As: Ubiquinone, Ubidecarenone.
Coenzyme Q10: Clinical Applications beyond Cardiovascular Diseases
CoQ10 and Cognition a Review and Study Protocol for a 90-Day Randomized Controlled Trial Investigating the Cognitive Effects of Ubiquinol in the Healthy Elderly
Investigation of coenzyme Q10 status, serum amyloid-β, and tau protein in patients with dementia
Prolonged Intake of Coenzyme Q10 Impairs Cognitive Functions
DHA
DHA (Docosahexaenoic Acid) is a long-chain omega-3 fatty acid crucial for brain health and cognitive function. Also Known As: 22:6(n-3) (scientific notation for its chemical structure)
Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease
Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease: A Randomized Trial
The Supplementation of Docosahexaenoic Acid-Concentrated Fish Oil Enhances Cognitive Function in Puppies
Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline
Ginkgo Biloba
Ginkgo Biloba, often simply called Ginkgo, is one of the oldest living tree species, renowned for its medicinal properties, particularly in enhancing cognitive function. Also Known As: Maidenhair Tree.
Randomized Clinical Trials Testing the Improvement of Cognitive Function of Ginkgo biloba Extract in Healthy People and Alzheimer's Patients
Neuroprotective and Antioxidant Effect of Ginkgo biloba Extract Against AD and Other Neurological Disorders
Effectiveness and safety of Ginkgo Biloba preparations in the treatment of Alzheimer's disease: A systematic review and meta-analysis
Ginkgo Biloba in the Aging Process: A Narrative Review
Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease
Jyotishmati
Jyotishmati, scientifically known as Celastrus paniculatus, is a climbing shrub traditionally used in Ayurvedic medicine for its cognitive-enhancing properties Also Known As: Intellect Tree, Malkangani, Staff Tree.
Behavioral and Biochemical Evidences for Antidepressant-Like Activity of Celastrus Paniculatus Seed Oil
Neuroprotective potential of Celastrus paniculatus seeds
L-Theanine
L-Theanine is an amino acid well-known for its calming effects on the brain, often found in green tea. Also Known As: γ-Glutamylethylamide, Green tea extract
L-theanine, a natural constituent in tea, and its effect on mental state
The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels
Green tea effects on cognition, mood and human brain function
A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study
Effect of Green Tea Phytochemicals on Mood and Cognition
Lions Mane Mushroom
Lion's Mane Mushroom, scientifically known as Hericium erinaceus, is a unique, edible fungus celebrated for its brain health benefits. Also Known As: Yamabushitake, Hedgehog Mushroom, Satyr's Beard.
Neurotrophic properties of the Lion's mane medicinal mushroom
The effects of twenty-one nutrients and phytonutrients on cognitive function
Therapeutic Potential of Hericium erinaceus for Depressive Disorder
Magnesium L-Threonate
Magnesium L-Threonate is a form of magnesium that is especially effective in crossing the blood-brain barrier, enhancing cognitive functions. Also Known As: Magnesium L-Threonate, Magtein™ (a patented form of Magnesium Threonate).
Regulation of structural and functional synapse density by L-threonate through modulation of intraneuronal magnesium concentration
Enhancemenmt of Learning and Memory by Elevating Brain Magnesium
Elevation of Brain Magnesium Prevents and Reverses Cognitive Deficits and Synaptic Loss in Alzheimer's Disease
A Megtein(R), Magnesium L-threonate, - based formula improves brain cognitive functions in healthy CA
Magnesium Orotate
Magnesium Orotate is a compound that combines magnesium with orotic acid, known for its ability to support heart health and enhance cellular energy production. Also Known As: Magnesium salt of orotic acid.
The effect of Magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial
Panax Ginseng
Panax Ginseng, often referred to as Korean or Asian Ginseng, is a highly valued herb known for its adaptogenic properties and cognitive-enhancing effects. Also Known As: True Ginseng, Korean Ginseng, Asian Ginseng.
Panax ginseng enhances cognitive performance in Alzheimer disease
Panax ginseng clinical trials: Current status and future perspectives
Passionflower
Passionflower, scientifically known as Passiflora incarnata, is a flowering plant renowned for its calming and sleep-inducing properties. Also Known As: Maypop, Purple Passionflower, Wild Apricot.
A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality
Passiflora incarnata in Neuropsychiatric Disorders-A Systematic Review
Effects of Passiflora incarnata Linnaeus on polysomnographic sleep
Pine Bark
NZ Pine Bark, derived from the bark of pine trees, is known for its rich content of proanthocyanidins, powerful antioxidants that support various health functions. Also Known As: Often associated with specific species, such as Maritime Pine Bark (Pinus pinaster), from which the well-known extract Pycnogenol® is derived.
Evaluation of the effects of pycnogenol (French maritime pine bark extract) supplementation on inflammatory biomarkers and nutritional and clinical status in traumatic brain injury patients in an intensive care unit
Resveratrol
Resveratrol is a natural polyphenol known for its potent antioxidant properties and its role in promoting longevity and heart health. Also Known As: 3,5,4'-trihydroxystilbene.
Idebenone and resveratrol extend lifespan and improve motor function
Brief Communication: SIR-2.1-dependent lifespan extension of Caenorhabditis elegans by oxyresveratrol and resveratrol
Dietary Mitophagy Enhancer: A Strategy for Healthy Brain Aging
Targeting mTOR signaling by polyphenols
Rhodiola Rosea
Rhodiola Rosea, commonly known as Golden Root or Arctic Root, is a herb renowned for its adaptogenic properties and ability to enhance mental and physical stamina. Also Known As: Roseroot, King's Crown.
Salidroside, a Bioactive Compound of Rhodiola Rosea, Ameliorates Memory and Emotional Behavior
Nootropic Herbs, Shrubs, and Trees as Potential Cognitive Enhancers
TMG
Betaine Trimethylglycine, commonly known as Betaine, is a compound derived from the amino acid choline and is known for its role in methylation processes in the body.
Also Known As: TMG, Glycine Betaine
Effects of betaine on performance and body composition
Effect of homocysteine-lowering nutrients on blood lipids: results
Beneficial Effects of Betaine: A comprehensive Review
Tart Cherry
Tart Cherry, scientifically known as Prunus cerasus, is a fruit known for its rich antioxidant content and natural sleep-enhancing properties. Also Known As: Sour Cherry, Montmorency Cherry (a popular variety).
Effect of tart cherry (Prunus cerasus) on melatonin levels
Pilot Study of the Tart Cherry for the Treatment of Insomnia
